Development of acute pancreatitis after oral administering a praziquantel, pyrantel pamoate, and febantel combination in a dog: A case report

Oral praziquantel, pyrantel pamoate, and febantel combination (PPFC) is a highly safe anthelmintic treatment commonly administered for the purpose of canine gastrointestinal parasites with mild adverse effects such as anorexia, vomiting, lethargy, or diarrhea. A 12-year-old castrated Chihuahua was brought to our hospital periodic health examination. Although his general physical examination showed no abnormalities, blood test results increase in liver enzyme, lipase activity, total bile acid, cholesterol, triglyceride concentration. Moreover, dog had underlying tricuspid regurgitation that not treated. PPFC prescribed on suspicion tract parasites. Following oral administration at home, anorexia lethargy were found, vomiting diarrhea noted after 30 h. The diagnosed acute pancreatitis based clinical course disease subsequent pathology results. intravenous drip initiated upon hospitalization, discontinued owing financial reasons. onset can be considered an effect PPFC. association between could clarified this case, may have been associated decrease function and/or false activity lipase. has dogs, although care should taken when administering medications dogs suspected having disorder.